1. Dr. Paul M. Matthews. Multiple sclerosis and brain MRI expert. Biography. 0
Dr. Paul M. Matthews, MD, explains his distinguished career in translational neuroscience. He holds prestigious academic and research leadership positions at Imperial College London.
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2. Multiple Sclerosis. How loss of neurons affects prognosis. 1
Dr. Paul Matthews, MD, explains how axonal and neuronal loss drives disease progression. He details the paradigm-shifting research that redefined MS as a neurodegenerative condition....
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3. Multiple Sclerosis treatment. Rituximab, Quilizimab, Brain’s lymph vessels Part 1 of 3. 7
Dr. Paul Matthews, MD, explains recent breakthroughs in personalized medicine. He highlights the landmark rituximab trial that transformed MS immunology by targeting B-cells.
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4. Multiple Sclerosis diagnosis and prognosis. Brain MRI and PET CT. Part 1 of 2. 11
Dr. Paul Matthews, MD, explains how advanced MRI and PET CT technologies are revolutionizing diagnosis and prognosis. He details the use of optical coherence tomography...
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5. Early Stage Multiple Sclerosis. Neurodegeneration and progress to disability. Part 1. 2
Dr. Paul Matthews, MD, explains how axonal loss begins early in MS and drives permanent disability. He details how MRI techniques can measure brain volume...
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6. Multiple Sclerosis treatment. Neuromyelitis optica. Tysabri. Precision medicine. Part 2 of 3. 8
Dr. Paul Matthews, MD, explains major breakthroughs in personalized medicine for MS. He details how genetic research confirmed MS as a primary autoimmune disease.
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7. Multiple Sclerosis diagnosis and prognosis. Antibody-based MRI. Quantitative MRI. Part 2 of 2. 12
Dr. Paul Matthews, MD, explains how MRI technology is rapidly evolving. He details advancements in speed, sensitivity, and novel contrast agents.
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8. Early Stage Multiple Sclerosis. Neurodegeneration and progress to disability. Part 2. 3
Dr. Paul Matthews, MD, explains how early brain damage in MS does not immediately cause disability. He details the brain's remarkable capacity for adaptive repair...
Dr. Paul Matthews, MD, explains the heterogeneity of multiple sclerosis as a clinical syndrome. He details how patients experience vastly different disease courses, from benign...
Dr. Paul Matthews, MD, explains how neuromyelitis optica (NMO) was redefined as a distinct disease from MS. He details the role of the Aquaporin-4 antibody...
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11. Multiple sclerosis. Recovery from relapse. How to improve neurological function? 6
Dr. Paul Matthews, MD, explains how neurological function recovers after a relapse. He details the brain's remarkable plasticity and redundancy. Recovery mechanisms include neuronal repair,...
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12. First symptoms of Multiple Sclerosis. What age of onset means for treatment and prognosis of multiple sclerosis. 10
Dr. Paul Matthews, MD, explains how age of onset impacts disease progression and treatment. His sophisticated MRI analysis reveals older patients experience more aggressive neurodegeneration....
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13. Multiple Sclerosis treatment. 11 new mediations. But how to choose correct mediation? Part 3 of 3. 9
Dr. Paul Matthews, MD, explains how personalized medicine is advancing treatment. He details the importance of real-world clinical effectiveness research.
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14. Patient – Doctor relationship in the age of precision medicine. 13
Dr. Paul Matthews, MD, explains the evolution of the patient-doctor relationship. He details the shift from a service model to a collaborative partnership.
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15. Stratified Medicine. Precision medicine for best treatment of multiple sclerosis. Estimation of prognosis. 14
Dr. Paul Matthews, MD, explains how stratified medicine improves treatment. He details how grouping patients by disease characteristics and prognosis informs therapy choices.
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16. Precision Pharmacology. Drug discovery. Personalized treatment of multiple sclerosis. 15
Dr. Paul Matthews, MD, explains how precision pharmacology revolutionizes drug development. He details the concept of targeting the right molecule at the right time and...
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