1. Dr. C. Richard Boland. Colorectal cancer expert. Biography. 0
Dr. C. Richard Boland, MD, details his pivotal research on hereditary colon cancer, career spanning over 40 years, and influential leadership roles including presidency of...
Dr. C. Richard Boland, MD, explains how this genetic condition increases cancer risk, the importance of early diagnosis through genetic testing, and why regular screening...
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3. Colon cancer symptoms. Colorectal cancer signs. 2
Dr. C. Richard Boland, MD, explains the often silent symptoms of colon cancer, differences between proximal and distal tumor presentations, and how regular screening prevents...
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4. Familial colon cancer. Colorectal cancer genetic cause. 3
Dr. C. Richard Boland, MD, explains how familial colon cancer syndromes develop through different genetic pathways, including Lynch syndrome, adenomatous polyposis, and rare conditions like...
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5. Familial colon cancer. Age of onset. How to prevent hereditary colon cancer? 4
Dr. C. Richard Boland, MD, explains how hereditary colon cancer develops earlier than sporadic cases due to inherited gene mutations, why family history and biomarkers...
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6. Colorectal cancer prognosis. Epigenetics. DNA methylation importance. 5
Dr. C. Richard Boland, MD, explains how DNA methylation drives 30-40% of cancers through silencing tumor suppressor genes, with specific focus on the CpG Island...
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7. Colorectal cancer prognosis. DNA methylation and microRNA levels predict cancer survival. 6
Dr. C. Richard Boland, MD, explains how DNA methylation patterns and microRNA levels serve as powerful biomarkers for predicting cancer prognosis and personalizing treatment. His...
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8. Colorectal cancer. Precision medicine therapy. Microsatellite Instability. 7
Dr. C. Richard Boland, MD, explains how microsatellite instability (MSI) impacts treatment selection and prognosis in colon cancer. He details how 15% of colorectal tumors...
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9. Colorectal Cancer Immunotherapy. Keytruda. Pembrolizumab. 8
Dr. C. Richard Boland, MD, explains how microsatellite instability (MSI) testing transforms treatment selection, why immune checkpoint inhibitors like Keytruda (pembrolizumab) outperform chemotherapy for MSI-high...
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10. Colorectal cancer and inflammation. Ulcerative colitis and cancer risk. 9
Dr. C. Richard Boland, MD, explains how chronic inflammation dramatically increases cancer risk throughout the digestive system, particularly in conditions like ulcerative colitis, primary sclerosing...
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11. Viral infection and colorectal cancer. 10
Dr. C. Richard Boland, MD, explores the potential link between viral infections and colon cancer development, discussing the JC virus hypothesis, research challenges, and why...
Dr. C. Richard Boland, MD, explains how curcumin—the active compound in turmeric—reduces inflammation and may prevent colon cancer. Research shows populations consuming 300 mg daily...
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13. 精密医療によるがん化学療法。計算に基づく治療戦略。第1部。12
計算化学療法の数学的モデリングが、大腸癌、悪性黒色腫、膵臓癌において腫瘍耐性を克服し治癒率を高める仕組みについて、がん遺伝学と精密医療の権威であるC. Richard Boland医学博士が解説します。この画期的な手法は、従来の逐次療法に代わり、分子的逃避と癌再発を防ぐ最適化された薬剤併用療法を実現します。
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14. Cancer chemotherapy precision medicine. Calculated treatment. Part 2. 13
Dr. C. Richard Boland, MD, explains how mathematical modeling transforms chemotherapy selection from trial-and-error to precision-calculated treatment, using tumor proliferation rates, death rates, and mutation...
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15. Colorectal cancer tumor markers. Cancer therapy efficacy prediction. 14
Dr. C. Richard Boland, MD, explains how the miR-21 microRNA tumor marker revolutionizes colon cancer screening and prognosis. This blood-based biomarker helps identify high-risk patients...
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16. Colorectal cancer screening. MicroRNA in blood and feces. How to find early colon cancer. 15
Dr. C. Richard Boland, MD, explains how microRNA biomarkers in blood and fecal samples offer a promising non-invasive method for early colon cancer detection. He...
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17. “Cancer Family: the search for the cause of hereditary colorectal cancer”. Book by Dr. C. Richard Boland. 16
Dr. C. Richard Boland, MD, shares his personal journey uncovering the genetic cause of Lynch syndrome in his family. His book details how early-onset colon...
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